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Shepherd says

Diagnosis typically involves measuring thyroid stimulating hormone (TSH) as the first-line test, with elevated TSH and low free T4 confirming hypothyroidism

Outcomes The primary objective was to compare change from baseline to week 3 in energy intake during ad libitum test meals for tirzepatide and placebo

SPPARM (pemafibrate) is promising in NASH patients with dyslipidemia
You would run the new workflow in parallel for a short period, then cut over