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Providing a direct link, -arrestin has been found to be necessary for the antiapoptotic effects of GLP-1 (186) and GLP-1 administration to a -cell line reduces H 2 O 2 -induced apoptosis through both cAMP and PI3K (but not ERK1/2) signaling with independent but additive effects (97)

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Granata A, Maccarrone R, Anzaldi M, Leonardi G, Pesce F, Amico F et al (2022) GLP-1 receptor agonists and renal outcomes in patients with diabetes mellitus type 2 and diabetic kidney disease: state of the art