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In the SURPASS-2 trial, patients with obesity and T2D who received tirzeapatide (5 mg weekly) achieved greater HbA1c and body weight reductions than those receiving semaglutide (1 mg weekly) during the 40 week study (64) despite comparable putative GLP-1R occupancy at these doses (65)

Despite this, it is thought that this new generation of therapeutics represents a historical inflection point in the advancement for improving obesity and related chronic metabolic diseases

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89% of them were female

Some patients may require ongoing Semaglutide GLP-1 treatment to prevent weight regain, while others may transition to a reduced dosage or discontinue the medication altogether

What is GLP-1 and how does it affect blood sugar