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While they can be effective in helping individuals lose weight, there are potential risks associated with their use, including the risk of malnutrition

Carlat Verdict: To prevent metabolic side effects when beginning an antipsychotic, start with metformin, but consider a GLP-1 RA for patients who have already been on antipsychotics for a while with a BMI 30 kg/m 2 (or 27 kg/m 2 and obesity-related health problems)

For clinicians used to watching kidney disease march forward despite treatment, these results were a massive shift

Wider Implications of the Findings The 2023 International Guideline for the Assessment and Management of PCOS provides clinicians and patients with clear advice on best practice, based on the best available evidence, expert multidisciplinary input and consumer preferences

The government awarded a $20 million grant over six years to develop what Walker calls a "bitter brake" mechanism, targeting the release of major appetite-suppressing hormones like GLP-1 , CCK , and PYY through bitterness delivered to the gut

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