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Its because we have seen use that is well beyond therapeutic reasons. Following the success of an extremely lean Pauline Ferrand-Prvot in this years womens Tour de France, rival Marlen Reusser, who is also a doctor, was among those to express concerns

No human clinical trial has evaluated doses exceeding 12 mg weekly

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But remember the 28-day stability rule: once reconstituted, the solution should be used within 28 days