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Although GLP-1 expression is highest in the large intestine, a large fraction of GLP-1-secreting EECs populate the small intestine 16

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In summary, convergent evidence from both preclinical and clinical research underscores the capacity of GLP-1RAs to interact with neural circuits that govern reinforcement and motivation, networks that are also targeted by drugs of abuse

The ARVO abstract did not comment on the NAION result, which runs counter to several previous studies showing an elevated risk

Maintaining Your Results After Treatment Transitioning Off GLP-1 Medications Deciding when and how to stop GLP-1 therapy requires careful planning with your healthcare provider

Nausea typically peaks weeks 4-5 and resolves within 8 days