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Additionally, some absorption enhancers require high concentrations to open tight junctions because of the buffering effect, which may induce GI-related adverse effects such as nausea, diarrhea, vomiting, and constipation [29]

Lancet 397:17361748 Lau DCW, Erichsen L, Francisco AM, Satylganova A et al (2022) Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial

Trulicity side effects The most common side effects of Trulicity are: nausea diarrhea vomiting stomach (abdominal) pain decreased appetite

Those kinds of labs

PMID 35441470 Rubino D et al

And so if you're using it like you're a lazy person