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The mean changes from baseline to week 26 were -0.9 kg and -3.4 kg in the placebo and RYBELSUS 14 mg arms, respectively

If necessary, prime the pen according to manufacturer instructions

Although generally safe, risks to also consider are allergic reactions, use during pregnancy, and low blood sugar levels.7 The mechanism of GLP-1 & GIP agonist has offered a multifaceted approach to treating both type 2 diabetes and obesity

The growing demand has also led to a surge of providers entering the market

Higher mean age and baseline SBP, greater use of anti-hypertensive medications, longer T2D duration, and reduction in insulin daily dose might have contributed to explain the difference observed in the impact of weight loss on SBP reduction in these trials, although direct GLP-1R- and GIP-R-mediated effects could also be considered [77]

1 Ribeiro CB, et al