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[6] [9] According to NICE guidance (NG28), GLP-1 receptor agonists are recommended as part of a comprehensive treatment strategy for type 2 diabetes that includes dietary modification, increased physical activity, and other glucose-lowering therapies when appropriate

Protocol 4: the medication transition plan Goal: Switch between GLP-1 medications without losing coverage or creating dangerous overlap Schedule (example: tirzepatide to semaglutide): Take last tirzepatide dose on day 0 Begin semaglutide at starting dose (0.25 mg) on day 7 Follow standard semaglutide escalation from there Why the plotter supports this: The plotter shows that seven days after your last tirzepatide dose, approximately 38% remains in your system

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2021;131 Mroz PA, Finan B, Gelfanov V, Yang B, Tschp MH, DiMarchi RD, et al