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Furthermore, altered feedback mechanisms between the small intestine and stomach, such as excessive duodenal sensitivity to acids or fats, may worsen dyspeptic symptoms and delay gastric emptying [31]

[DOI] [PMC free article] [PubMed] [Google Scholar] 112.Karunaratne T., Yan Y., Eubanks A., Inman B., Rao S., Sharma A

These approaches work by stimulating the L-cells in your intestinal lining or by improving the sensitivity of GLP-1 receptors throughout your body

Thats a conversation to be had, and I really want listeners to hear that clearly

GLP-1 RAs can be used in combination with multiple oral antidiabetic drugs or in combination with insulin (282)

Many people need long-term or indefinite treatment to maintain weight loss
