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Yes, though many patients in this range do well on a lower-dose semaglutide protocol with a planned exit strategy rather than long-term use

Abbreviations BBB: Blood-brain barrier CGRP: Calcitonin gene-related peptide CM: Chronic migraine CNS: Central nervous system CSD: Cortical spreading depression DMEM: Dulbeccos modified Eagles medium FBS: Foetal bovine serum GLP-1R: Glucagon-like peptide-1 receptor IGF-1: Insulin-like growth factor-1 IS: Inflammatory soup LPS: Lipopolysaccharide NTG: Nitroglycerin PI3K: Phosphoinositide 3-kinase PKA: Protein kinase A PMSF: Phenylmethylsulfonyl fluoride RT: Room temperature TNC: Trigeminal nucleus caudalis References May A, Schulte LH (2016) Chronic migraine: risk factors, mechanisms and treatment
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It's still there, just under some protective padding you didn't ask for

The pH effect was also studied from 3 to 5

This plateau is a normal physiological response, not a sign of treatment failure, and multiple evidence-based strategies can help restart your momentum
