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[DOI] [PMC free article] [PubMed] [Google Scholar] Kobilka B

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Concurrently, high glucose suppressed the tumor suppressor TIF1, further amplifying Smad-mediated transcription and elevating the expression of pro-oncogenic genes, including the epithelialmesenchymal transition markers N-cadherin and vimentin, thereby collectively fostering CRC progression

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Distinguishing tachyphylaxis from other explanations requires systematic evaluation

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