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Weight loss typically follows within weeks
However, persistent flushing, severe sweating, fever, rapid heartbeat, or worsening symptoms should still be medically reviewed to rule out other underlying causes

Otherwise, patients taking both a DPP4i and GLP1-RA could benefit from discontinuing the DPP4i

Work with your doctor, start low and slow, keep a symptom diary, and dont ignore severe nausea or bile vomiting

Starting sequence If you are starting both therapies simultaneously, most providers recommend establishing HRT first
