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It works by mimicking a natural hormone that tells your brain you're full, which helps reduce appetite and calorie intake

(2024) 47:S158S78

Those numbers represented a massive leap

see also review by Brierley & de Lartigue, 2021), or even elsewhere close to the circulation, which in turn release glutamate and peptide cotransmitters within the lower brainstem to convey postprandial satiation signals to the CNS (Figure 1)

In the current review, we will provide an overview of how the gutbrain axis contributes to metabolic homeostasis, highlighting some of the novel ideas as to how this gutbrain communication is mediated