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Large-scale clinical trials, including the SELECT cardiovascular outcome trial with over 17,000 participants, have not demonstrated increased overall cancer incidence with these medications compared to placebo groups

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As of 2021, approximately 537 million adults were living with diabetes, and about 1.4 million new cases of diabetes are diagnosed in the United States every year

Caloric restriction in humans: impact on physiological, psychological, and behavioral outcomes

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doi:10.1073/pnas.0806720106