gaining weight on glp 1 Real-world studies of GLP-1 discontinuation showed that patients often regain at a significantly faster pace than after other weight-loss methods. At the same time, however, novel strategies aimed at countering those Penn researchers say inconsistent GLP1
Description
I think those are the big two factors

Sclerostin, encoded by the SOST gene, is secreted by osteocytes and suppresses bone formation

In the case of a meta-analysis with a negative result, it is crucial to establish if the pooled information is sufficiently powered to exclude the association between the factor being studied (GLP-1 agonist use) and the outcome (pancreatic cancer)

Psychiatry 50 , 702703 (2016)

FDA approves Lilly's Foundayo (orforglipron), the only GLP-1 pill for weight loss that can be taken any time of day without food or water restrictions

Here, the combination with other drugs such as RAAS blockers, SGLT2 inhibitors, and mineralocorticoid receptor agonists, which have also displayed renoprotective effects, needs to be taken into account as well
