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For many individuals, Isotretinoin results in long-term remission of acne, with permanent improvement in skin condition

Jama , 302 (22), pp.2437-2443

For group 2 (in which participants were recruited from different sites), site was added to the model, so the full model included site, treatment, period nested within site, sequence, sequence nested within site and participant nested within sequence and site

Which treatment you get is decided by chance and you will not know if you are taking the active tablet