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In clinical trials, patients on Topamax showed significant improvements compared to those on a placebo, with a marked decrease in the number of binges

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It is true that the number of patients studied is not very large and that larger randomized clinical trials in non-obese patients are not included, so the results cannot be generalized to the general population

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Methods A previously published and validated mathematical model of human energy metabolism and body composition dynamics (3, 6) was recently modified to represent feedback control of energy intake in response to interventions that induce negative energy balance (4, 5)

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Self-sourcing or self-dosing of retatrutide outside a physician-supervised plan is not supported by this clinic

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Others mention better digestion and reduced bloating, which could be a prebiotic effect from the polyphenols

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