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Yufang Lin, an integrative medicine specialist at the Cleveland Clinic

But new research presented in late 2025 suggests that when it comes to actual, sustained weight loss in real-world patients, surgery still outperforms these medications by a wide margin

Its not just extra pounds, but also where that fat is stored that changes in perimenopause (the years before your period stops) and menopause

Physician-supervised programs generally provide better long-term outcomes because they combine medication with education, accountability, and personalized medical care

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Ultimately, causality cannot be inferred from these observational findings