glp receptor 1 agonists Glucagon-like peptide-1 (GLP-1) are incretin analogues that promote glucose-mediated insulin release and are used to treat type 2 diabetes mellitus and #obesity. GLP-1 receptor agonists and GLP-1 and glucose-dependent insulinotropic Mechanisms of GLP-1 Receptor Agonist-Induced

Subgroup analysis in patients with positive baseline C-peptide levels showed a more robust reduction of HbA1c (i.e., 0.69-0.83%) on GLP-1RA in this group (56, 57)

doi: 10.1016/j.cmet.2019.03.002 61 GrunddalKVJensenEPrskovCAndersenDBWindelvJAPoulsenSSet al

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Clarke, S

In contrast, a pharmacological substrate is cleaved by DPP-4 ex vivo, but evidence for cleavage of the endogenous peptide in vivo may be lacking (e.g., aprotinin, BNP, -casomorphin, chorionic gonadotrophin, endomorphin-1, endomorphin-2, enterostatin, eotaxin, erythropoietin, GCSF [granulocyte colony stimulating factor], and many others)

The drugs work by mimicking GLP-1, a hormone the gut releases after eating that stimulates insulin release and suppresses glucagon to control blood sugar