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Complementary modeling studies suggest that GLP-1 RAs such as semaglutide and tirzepatide may disrupt the typical feedback loop in which weight loss leads to compensatory increases in appetite, potentially extending the period of reduction before plateauing occurs

Importantly, fertility is a long-term consideration spermatogenesis takes ~74 days, so any intervention or insult could take 23 months to manifest in semen changes

The findings challenge the assumption that weight regain after GLP-1 discontinuation is inevitable

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Citations Citations to this article as recorded by Risk of depression with GLP1 receptor agonists use in overweight or obese adults with type 2 diabetes: A newuser, activecomparator cohort study Yu Chang, MingHong Hsieh, PoChung Ju, ChengChen Chang Diabetes, Obesity and Metabolism.2026