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Trial SELECT (Lincoff et al., NEJM 2023) Design Phase 3 / 39.8 mo mean follow-up Population 17,604 adults with CVD + overweight or obesity, no diabetes Key result 20% reduction in major heart events (HR 0.80

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Weight loss of 2-4 pounds is common as your body adjusts

While these medications work through different mechanisms, it's worth noting that Wegovy delays gastric emptying, which could theoretically affect the absorption of some oral medicines, though this is not expected to be clinically meaningful with naproxen

Drucker DJ, Nauck MA (2006) The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

In these situations, I don't take the chance