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In the FLOW trial, which enrolled 3533 patients, treatment with Semaglutide (Table 2), a 24% reduction was observed in the urine albumin-to-creatinine ratio, alongside a decreased incidence of acute kidney injury, attenuation of CKD progression and a lower risk of progression to kidney transplantation

L-cells are known to modulate the release of their hormonal cargo in response to the activation of a plethora of receptors capable to sense fats, carbohydrates, proteins and many other compounds

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We emulated and benchmarked against two cardiovascular outcome trials (reference trials), SUSTAIN-6 (semaglutide versus placebo) and SURPASS-CVOT (tirzepatide versus dulaglutide) in a pair of cohort studies