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KarnewarSNeeliPKPanugantiDKotagiriSMallappaSJainNet al
Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility In mice and rats, standard two-year carcinogenicity studies with insulin glargine were performed at doses up to 0.455 mg/kg, which was for the rat approximately 65 times the recommended human subcutaneous starting dose of 0.2 Units/kg/day (0.007 mg/kg/day)
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Table of Contents Overview of GLP1 Receptor Agonists Biologic Rationale: How GLP1 Might Affect Bone Clinical Evidence on Bone Density Fracture Risk Data from GLP1 Trials Comparisons With Other Diabetes Therapies Practical Recommendations for Clinicians Future Research Questions FAQs About Bone Health and GLP1s Overview of GLP1 Receptor Agonists GLP1 receptor agonists mimic the natural hormone GLP1, enhancing insulin secretion and reducing glucagon release in a glucose-dependent manner
Vonlaufen A, Apte MV, Imhof BA et al
