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It is associated with many serious health consequences and reduced life expectancy

Appetite does normalize after stopping GLP-1 medication, but this doesn't erase your behavioral progress

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Successful combination therapy requires adequate protein intake, typically 1.6-2.2 grams per kilogram of body weight, and consistent resistance training to protect muscle mass

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however, administration of retatrutide at higher doses significantly reduced circulating FGF21 levels, suggesting that retatrutide efficacy in MASLD is unlikely to be attributable to increased FGF21 levels