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Mechanistic reviews highlight direct effects at GLP1R on islets, brain, and GI tract that explain both efficacy and common GI side effects

The FDA approval of the first oral GLP-1 medication for obesity in December 2025 represents a major milestone in weight loss treatment options

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In OASIS 4, gastrointestinal effects affected around 74% of those on the Wegovy pill compared with 42% on placebo, led by nausea (roughly 47% vs 19%) and vomiting (about 31% vs 6%), with diarrhoea and constipation also common