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If pancreatitis is suspected, Wegovy should be discontinued and appropriate diagnostic tests performed urgently Gallbladder problems : Rapid weight loss increases risk of gallstone formation, with cholelithiasis reported in approximately 1.6% of Wegovy users Intestinal obstruction/ileus : Cases have been reported in post-marketing surveillance, particularly in patients with pre-existing GI conditions Management strategies recommended by healthcare professionals include: Eating smaller, more frequent meals rather than large portions Avoiding high-fat, spicy, or heavily processed foods Staying well-hydrated, particularly if experiencing diarrhoea or vomiting, to prevent dehydration and potential acute kidney injury Not lying down immediately after eating to minimise reflux Ensuring adequate fibre intake to prevent constipation Taking the medication on the same day each week to maintain steady levels Most GI side effects improve over time as the body adjusts to the medication, typically becoming less troublesome after 4-8 weeks at each dose level

doi: 10.1038/nrm3512 8 AndersonRG

Researchers believe this additional pathway may provide important insights into energy expenditure, fat metabolism, and metabolic adaptation

Step 2: Preparation of compound of formula- 11 Ethanol (850 ml), DIPEA (64 ml) and 2-(2-(2-aminoethoxy)ethoxy)acetic acid compound of formula-10 (59.8 gm) were added to the compound obtained in step 1 at 25- 30C and stirred the reaction mixture for 1 hr at the same temperature

Mumbai: For thousands across the country, this year has brought a sudden relief from a lifetime of struggles with obesity, driven by the arrival of one weight-loss drug in March and then a couple more