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When and How to Adjust Doses Dose adjustments may be necessary if there are signs of declining kidney function or dehydration

Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor

The significant body weight difference between liraglutide-treated control and Liv Fgf21/ mice (Figure 3G) was associated with an attenuated, albeit not significant, reduction in fat-free (i.e., lean) mass in Liv Fgf21/ mice (Figure 3H)

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Although, most participants lost weight, there was heterogenicity, that has been well-documented in obesity studies [66] and those with higher BMI above 35 experienced greater mean percentage weight loss [64]

Increased GIP signaling induces adipose inflammation via a HIF-1alpha-dependent pathway and impairs insulin sensitivity in mice