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community, species, pathway, gene, and metabolite) can affect a host phenotype (e.g
Ross CA, Ruggiero DA, Joh TH, Park DH, Reis DJ

In clinical trials, up to 20.3% of patients experienced nausea

And the caloric restriction from medication means additional restriction from fasting requires more careful calibration

Decreased receptor sensitivity at target tissues has also been observed in some research contexts

In such cases, lower doses are often useful to monitor tolerance
