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10.1172/JCI112855 56

Unlike small-molecules, generic peptides often require a clinical efficacy trial, an immunogenicity assessment, and impurity determinations

doi: 10.1007/s00394-020-02473-0 12

Our study provides evidence for an important mechanism by which GLP-1 analogues improve glucose homeostasis in T2D patients, unveiling new aspects that could be useful for developing new therapeutic strategies

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Animals received either liraglutide (25 nmol/kg/day i.p.) or dorsomorphin, an AMPK inhibitor, (2.5 mg/Kg i.p.) 30 min before the liraglutide dose, for 4 weeks (starting from the second week)