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This overlap makes baseline IBD control essential before starting GLP-1 therapy and close monitoring during titration critical for distinguishing medication effects from disease activity

Day-to-day fluctuations are normal, but a graph can make a 3-pound gain easy to catch before it becomes 20

Table 1 Physical activity recommendations in people with obesity on GLP-1RAs

Garvey WT, Frias JP, Jastreboff AM et al (2023) Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial

Data from obesity trials involving semaglutide indicate that patients who restart treatment often respond again, especially if the interruption is not prolonged