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Most patients lose 10% to 15% within the first year, with continued gradual loss through month 18

A patient with a BMI of 35 aiming for a BMI under 25 follows a different timeline than someone with a BMI of 28, and genetic testing can predict which patients typically respond faster

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[DOI] [PubMed] [Google Scholar] 29.Talley NJ, et al

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However, excessive PARP1 activation, due to exposure to genotoxic agents, can dramatically reduce NAD + and ATP levels, affecting sirtuin activity and cellular homeostasis and leading to cell death