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Understanding Weight Loss Outcomes with GLP-1 TreatmentsYouve committed to a GLP-1 weight loss program, followed the plan, waited patientlybut the scale barely moves

Similar exposureresponse relationships were observed for efficacy (HbA1c and body weight) and tolerability (nausea and vomiting) of semaglutide, regardless of the route of administration [58]

10.1016/j.lfs.2025.123407 [DOI] [PubMed] [Google Scholar] 36

No data have been reported in preclinical models with semaglutide

Anti-diabetic drugs and sarcopenia: emerging links, mechanistic insights, and clinical implications

YES, and translation to the clinic is on the way Complete masterclass by @h_sokol #DDW2025 Modify gut microbiota impacts disease severity In mice models In humans (FMT) Faecal microbiota from patients with IBD exacerbate colitis in mice Altered gut microbiota in IBD bacteria and fungi and viruses with decreased diversity and change in composition The alterations in the gut microbiome precede development of CD by several years and occur in the absence of inflammation in the gastrointestinal tract (GEM study) Therapeutic strategy Hit the bad guys: Antibiotics _ risk of antibiotic resistance and toxicity Phages _ advantages as more targeted Boost the good guys: FMT has some effect but impossible to standardise