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The American Diabetes Association (ADA) emphasizes that pharmacotherapy for diabetes and obesity often requires long-term or indefinite continuation to maintain benefits, though this does not necessarily mean every patient must remain on the same medication permanently

[DOI] [PubMed] [Google Scholar] 72.Yin W., Xu S., Wang Z., et al

Revised: January 2026 ZEPKP-0002-IFU-20260121 NDC 0002-2506-80 Zepbound (tirzepatide) injection 2.5 mg/0.5 mL 4 x 2.5 mg/0.5 mL prefilled pens Rx Only For Subcutaneous Use Dispense enclosed Medication Guide to each patient

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Clinical trial data shows that 82% of participants achieved at least 5% weight loss by week 12, which researchers consider a strong indicator of long term success with the medication