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[18] conducted a double-blind phase 2 trial involving participants with biopsy-confirmed NASH (and liver fibrosis at stage F1, F2, or F3) (treatment for 72 weeks)

The numbers tell a specific story, one that most summaries of retatrutide gloss over entirely

P = 0.02) and in SELECT trial (HR 0.80

Unlike injectable GLP-1 receptor agonists, which bypass the stomach, the oral formulation relies on an absorption enhancer to facilitate uptake in the gastrointestinal tract

More powerful injections on the horizon: Lillys experimental drug retatrutide produced nearly 29% average weight loss in trials the highest seen yet but with higher dropout rates due to side effects.

Their results suggested that GLP-1RA could inhibit atrial arrhythmogenesis, and improve conducting properties as well as fibrosis in myocardial infarction-induced heart failure