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These findings underscore the importance of smoking cessation for mitigating the effects of smoking on BP

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10.1111/prd.12036 4

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Furthermore, tetrahydrobiopterin (BH4), a cofactor for eNOS, was associated with improved vasodilation to acetylcholine in chronic smokers, but not tetrahydroneopterin (NH4), suggesting that reduced NO bioactivity in chronic smokers is partially caused by reduced BH4 availability and that NOS-mediated superoxide production is an important source of superoxide in chronic smokers 20)