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These factors can include race/ethnicity, cultural characteristics, acculturation, social marginalization (e.g., Lesbian, Gay, Bisexual and Transgender communities, people with mental illness and substance abuse disorders), stress, tobacco industry influence, lack of comprehensive tobacco control policies, and lack of community empowerment

With antidepressants, people may also refer to this as antidepressant poop out or antidepressant tolerance. Research notes that tachyphylaxis may occur in up to 33% of people that take antidepressants for depression

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