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After activation, Nrf2, a nuclear factor, can induce MDM2-mediated Rb proteosomal degradation by promoting MDM2 expression, which might block the Rb/E2F pathway that mediated the inhibitor of cell-cycle progression of infected hepatocytes 82

Radiation induces p53-dependent cell apoptosis in bladder cancer cells with wild-type- p53 but not in p53-mutated bladder cancer cells

Suppressing HOTAIR decreases the expression of PKR as well as TNF - and IL - 6

Mutant p53 suppresses innate immune signaling to promote tumorigenesis

When UVR-induced DNA damage occurs before entry into the S phase, p53 halts the cell cycle at the G1 phase in part by transcriptionally inducing cyclin-dependent kinase inhibitor ( CDKN1A) , also known as p21 (WAF1/CIP1), a potent inhibitor of several cyclin-dependent kinase complexes

Experimental validation of miRNA targets