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Although DOI is quite potent, it likely never became popular as a street drug because of its very prolonged duration of action, so it had never been placed into Schedule I of the Controlled Substances Act (although as of November 2015, there are congressional moves afoot to change that)

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And a bottle of e-liquid, which will last even heavy smokers about a month, costs around $15 to $20

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Best practices for monitoring TMV mutation and the impacts of TMV mutation on virus usability are not well established