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So for animals, the high sugar content of an overly ripe fruit signaled high nutrition leading to inadvertent intoxication among early species

Its called COMMON SENSE

Psychiatry 80, 198206

The levels of creatinine clearance and glomerular filtration rate were decreased and the difference between the GFR and creatinine clearance of the two experimental groups was not statistically significant with the normal healthy controls (Figure 3)

Out of nowhere, I decided to try again, but with the actual cigarette lighter coil removed from the jack

There is not much going on with this class of compounds now, says tobacco studies expert Robert West at University College London, who doesnt foresee any work in this area in the near term