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The assessed toxicants covered a range of different chemical classes including various carbonyls, polyaromatic amines and metals with some also being of public health interest to regulatory and public health bodies like the US FDA and WHO

On the other hand, heat-not-burn products heat tobacco to significantly lower temperatures that do not exceed 350 degrees Celsius, without burning it, and therefore produce no smoke

The latest mods have a feature called Temperature Control, or TC

The combined effects of local mucosal irritation and cellular damage due to the numerous carcinogenic substances found within cigarettes create the ideal environment for developing cancerous changes within cells

Regulatory Toxicology and Pharmacology

[95] With constant use of nicotine, tolerance occurs at least partially as a result of the development of new nicotinic acetylcholine receptors in the brain