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The short answer: it varies

Its a stimulant alkaloid found naturally in Nicotiana tabacum , concentrated mainly in the leaves, and while its one of several tobacco alkaloids, its the one responsible for the plants strongest physiological effects

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The calculation of NSDUH weights for analysis includes a step that yields weights consistent with population totals obtained from the U.S

A drug addicts life expectancy, beginning at the time the addiction starts, is only 15 to 20 years longer if the drug abuse goes untreated, according to an article on the long-term effects of drug use from Turnbridge