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Moreover, our in vitro study illustrated that the antifungal drugs, fluconazole and amphotericin B, alleviated the effect of nicotine on C

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Our data do not differ from the results obtained in other studies done previously in different populations: most previous casecontrol studies found similar associations between current smoking and the risk of developing RA, with ORs ranging from 1.42 [1.131.80] to 2.37 [1.563.60].6,9 Similarly, cohort studies have mostly found an excess risk associated with smoking.1012 Some controversial findings have however been published previously, that found no association between RA and smoking.13 Our study suggests that the effect of smoking on RA risk is long-lasting for years after smoking cessation, with ex-smokers still at an increased risk of developing RA compared to non-smokers