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spondylodysplastic, arthrochalasia, kyphoscoliotic, and classical-like type 2 EDS) [9, 43, 44, 48, 49, 52, 59, 65, 68] or skeletal dysplasia [39], and suggests a potential involvement of skeletal fragility in determining a poorer quality of life (QoL) in adult patients

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Conversely, adjusting for gender and exact age at scanning, but looking instead at rate of thinning in current smokers (to avoid confounding this rate by the effect of recovery that is observed in ex-smokers), revealed, within areas of pack-years-associated cortical thinning, that mean cortical thickness was 3.21 m thinner for every pack-year smoked (95% confidence interval, 5.82 to 0.60 m

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Smoking during adolescence increases the risk of developing psychiatric disorders and cognitive impairment in later life