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The implications for research, policy, and practice are considerable

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In addition, the charcoal burned in the pipes often produces its own toxins , including high levels of carbon monoxide and cancer-causing chemicals

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The question becomes more nuanced when considered within the complexities of the overall nicotine marketplace, most notably in relation to e-cigarettes, which appear to produce less-toxic emissions than not only conventional cigarettes but also IQOS

Cigarette smoke induces overexpression of active human cathepsin S in lungs from current smokers with or without COPD