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The lesion may be covered to prevent contaminating the environment or other people, although person-to-person spread is very uncommon Other infections Scabies can occasionally cause bullae on the feet in infants Tinea can occasionally cause localised bullae Others common causes of vesicles and bullae Eczema Pompholyx (figures 24-25) - a type of eczema that usually presents periodically with intensely itchy vesicles, and occasionally large bullae, that predominate on the palms and sides of fingers - refer to the chapter Eczema: hand (and foot) eczema Contact allergic dermatitis can occasionally cause blistering Papular urticaria (figure 26) Is a hypersensitive reaction to various insect bites It is more common on the lower legs, and other exposed sites Bullae can be small or large and are often grouped together, sometimes in a circular or linear arrangement Refer to the chapter Papular urticaria 3

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Risk factors for development of HCC in chronic HCV infection Approximately 20% of chronic HCV-infected individuals develop liver cirrhosis within 2030 years and once cirrhosis is established, the rate of HCC development is 14% annually

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