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I see that it has lately been discontinued anyway, so this review is otiose now
The dissimilarity matrix of vaginal metabolites was fitted with four of the variables listed in Table 2 and the final model was selected with the greatest adjusted R 2 value

I see two main elements of the path to addressing that concern
Other mutational signatures such as SBS5, 8, and 40 were also detected in Zhang et al., albeit not prominently and their etiologies remain largely unknown

Military officials have strongly discouraged use of tobacco products in recent years, spending billions on smoking cessation campaigns

And then I have that whole thing