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CEO: Larry Firestone Headquarters: Williamsville, New York URL: www.xxiicentury.com January 2011 APO Financing: $5,435,000 Trading Venue: NYSE American (XXII) 22nd Century is a plant biotechnology company whose proprietary technology through genetic engineering and plant breeding allows (i) the level of nicotine (and other nicotinic alkaloids) in the tobacco plant to be decreased or increased and (ii) the levels of cannabinoids to be decreased or increased in addition to the cannabinoid profile being tailored

12 Practitioners should ensure patients are counseled on the increased risks of cardiovascular and neurologic toxicity secondary to the high levels of caffeine contained in most energy drinks if prescribed one of the above drugs