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Characteristics of the cigarettes: tar 6 mg., Nicotine 0.5 mg

5.3 Peripheral Neuropathy Fluoroquinolones, including ciprofloxacin, have been associated with an increased risk of peripheral neuropathy

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Chemical irritants bind to receptors, which open ion channels on the terminals of the airway sensory nerves, leading to cation influx and membrane depolarisation