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J Clin Oncol (2012) 30(17):215762.10.1200/JCO.2011.40.1943 33 Van den BroeckTJoniauSClinckemalieLHelsenCPrekovicSSpansLet alThe role of single nucleotide polymorphisms in predicting prostate cancer risk and therapeutic decision making

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Tobacco, Inflammation, Oxidative Stress, and Hepatocellular Carcinoma: Connecting the Dots Tobacco smoking causes inflammation and chronic liver damage that activates liver stellate cells (HSCs), the key element in the initiation and progression of liver disease, a major risk factor in the development of hepatocellular carcinoma [49] (Figure 4)

However, you can reduce your risk of them by addressing the common predisposing risk factors